Prof. Dr. Gökhan SADİ

KARAMANOĞLU MEHMETBEY ÜNİVERSİTESİ K.Ö.FEN FAKÜLTESİ BİYOLOJİ BÖLÜMÜ

Makaleler

A. Uluslararası Hakemli Dergilerde Yayınlanan Makaleler (SCI & SCI-E)

  1. Aslan E, Sadi G, Guzel H, Karaca C, Korkmaz O, Pektas M, Celegen M, Aladag T, Oncu S, Pektas M (2023) Kefir Prevents Adipose Tissue Growth Through the Induction of Apoptotic Elements in High-Fructose Corn Syrup-Fed Rats. Polish J Food Nutr Sci 73:120–129.
  2. Guctekin Yasar O, Bostanci A, Karuk Elmas SN, Aydin D, Arslan FN, Sadi G, Yilmaz I (2023) A cyanobiphenyl–based fluorescent “‘lighting–up’” sensor for highly selective and sensitive recognition of Al3+: Theoretical, practical and bioimaging studies. Spectrochim Acta – Part A Mol Biomol Spectrosc 294:122556.
  3. Ekici Ö, Aslan E, Aladağ T, Güzel H, Korkmaz ÖA, Bostancı A, Sadi G, Pektaş MB (2022) Masseter muscle and gingival tissue inflammatory response following treatment with high-fructose corn syrup in rats: Anti-inflammatory and antioxidant effects of kefir. J Food Biochem 46:1–12.
  4. Akar F, Yildirim OG, Yucel Tenekeci G, Tunc AS, Demirel MA, Sadi G (2022) Dietary high-fructose reduces barrier proteins and activates mitogenic signalling in the testis of a rat model: Regulatory effects of kefir supplementation. Andrologia 54:e14342.
  5. Ekici O, Aslan E, Guzel H, Korkmaz OA, Sadi G, Gurol AM, Boyaci MG, Pektas MB (2022) Kefir alters craniomandibular bone development in rats fed excess dose of high fructose corn syrup. J Bone Miner Metab 40:56–65.
  6. Sumlu E, Bostancı A, Sadi G, Alcagir ME, Akar F (2022) Lactobacillus plantarum improves lipogenesis and IRS-1/AKT/eNOS signalling pathway in the liver of high-fructose-fed rats. Arch Physiol Biochem 128:786–794.
  7. Aydin D, Arslan FN, Karuk Elmas SN, Bostanci A, Akin Geyik G, Savran T, Sadi G, Yilmaz I (2022) A fluorescent chemoprobe based on 1,8–naphthalimide derivative specific for cellular recognition of cysteine over homocysteine and glutathione. J Photochem Photobiol A Chem 433:114119.
  8. Bal NB, Bostanci A, Sadi G, Dönmez MO, Uludag MO, Demirel-Yilmaz E (2022) Resveratrol and regular exercise may attenuate hypertension-induced cardiac dysfunction through modulation of cellular stress responses. Life Sci 296:120424.
  9. Sadi G, Bora H, Çiçek M, Koran K, Görgülü AO, Yılmaz İ (2022) Evaluation of Biological Activities and Enzyme Inhibitory Potential of 7,8-Dihydroxy-3-(4-methylphenyl) Coumarin. Rev Bras Farmacogn 32:749–758.
  10. Pektaş MB, Aslan E, Güzel H, Korkmaz ÖA, Çeleğen K, Pektaş A, Bostanci A, Sadi G (2022) Kefir protects the liver against high fructose corn syrup induced phosphodiesterase hyperactivity. Turkish J Biochem 47:351–360.
  11. Pektas SD, Kara M, Dogan G, Pektas MB, Baloglu MC, Sadi G (2022) Differential Expression and in Silico Functional Analysis of Plasma MicroRNAs in the Pathogenesis of Non‑segmental Vitiligo. Indian J Dermatol 67:705–714. https://doi.org/10.4103/ijd.IJD
  12. Emsen B, Sadi G, Bostanci A, Gursoy N, Emsen A, Aslan A (2021) Evaluation of the biological activities of olivetoric acid, a lichen-derived molecule, in human hepatocellular carcinoma cells. Rend Lincei 32:135–148.
  13. Savran T, Nihan Karuk Elmas S, Akin Geyik G, Bostanci A, Aydin D, Nur Arslan F, Sadi G, Yilmaz I (2021) “Turn-on” Fluorescence Chemosensor Based Probing of Cu2+ with Excellent Sensitivity: Experimental Study, DFT Calculations and Application in Living Cells and Natural Waters. ChemistrySelect 6:6286–6294.
  14. Aydin D, Karuk Elmas SN, Akin Geyik G, Bostanci A, Arslan FN, Savran T, Sadi G, Yilmaz I (2021) 1,8-Naphthalimide appended propiolate-based fluorescent sensor for selective detection of cysteine over glutathione and homocysteine in living cells. New J Chem 45:16617–16624.
  15. Aydin D, Karuk Elmas SN, Savran T, Arslan FN, Sadi G, Yilmaz I (2021) An ultrasensitive ″OFF–ON″ fluorogenic sensor based on thiazole derivative for Zn2+: Food supplement, water and bio–imaging applications. J Photochem Photobiol A Chem 419: 113459
  16. Akar F, Güney C, Özer H, Pektaş M, Koca H, Kocabaş A, Sadi G (2021) The inverse association between ANGPTL8 and PI3K-mTOR- PPARγ expressions in adipose tissue of high-fructose- fed rats: The modulatory effect of kefir. Istanbul J Pharm 51:299–306.
  17. Karuk Elmas SN, Karagoz A, Aydin D, Arslan FN, Sadi G, Yilmaz I (2021) Fabrication and sensing properties of phenolphthalein based colorimetric and turn–on fluorogenic probe for CO32− detection and its living–cell imaging application. Talanta 226:122166.
  18. Akar F, Sumlu E, Alçığır ME, Bostancı A, Sadi G (2021) Potential mechanistic pathways underlying intestinal and hepatic effects of kefir in high-fructose-fed rats. Food Res Int 143:.
  19. Kose MSH, Dogan M, Sadi G (2021) Enhanced in vitro shoot proliferation through nodal explants of Staurogyne repens (Nees) Kuntze. Biologia (Bratisl) 76:1053–1061.
  20. Emsen B, Sadi G, Bostanci A, Aslan A (2021) In vitro evaluation of cytotoxic, oxidative, genotoxic, and apoptotic activities of physodic acid from Pseudevernia furfuracea in HepG2 and THLE2 cells. Plant Biosyst 155:1111–1120.
  21. Karuk Elmas SN, Aydin D, Savran T, Caliskan E, Koran K, Arslan FN, Sadi G, Gorgulu AO, Yilmaz I (2021) A Fluorene based Fluorogenic “‘Turn-off’” Chemosensor for the Recognition of Cu2+ and Fe2+: Computational Modeling and Living-cell Application. Curr Anal Chem 18:204–216.
  22. Bozkurt E, Atay E, Pektaş G, Ertekin A, Vurmaz A, Korkmaz ÖA, Sadi G, Aslan E, Koca OH, Pektaş MB (2020) Potential anti-tumor activity of kefir-induced juglone and resveratrol fractions against ehrlich ascites carcinoma-bearing balb/c mice. Iran J Pharm Res 19:358–369.
  23. Karuk Elmas ŞN, Berk Gunay I, Karagoz A, Bostanci A, Sadi G, Yilmaz I (2020) A Novel Fluorescent Probe Based on Perylene Derivative for Hg2+ Ions and Biological Thiols and its Application in Live Cell Imaging and Theoretical Calculations. Electroanalysis 32:775–780.
  24. Yıldırım OG, Sadi G, Akar F (2020) Lactobacillus plantarum and Lactobacillus helveticus modulate SIRT1, Caspase3 and Bcl-2 in the testes of high-fructose-fed rats. Istanbul J Pharm 50:168–175.
  25. Elmas SNK, Gunay IB, Genc HN, Aydin D, Arslan FN, Sadi G, Sirit A, Yilmaz I (2020) A tetraoxacalix[2]arene[2]triazine based fluorogenic probe for the sensing of Fe3+: Computational and living–cell imaging applications. J Photochem Photobiol A Chem 403:112848.
  26. Aydin D, Gunay IB, Karuk Elmas SN, Savran T, Arslan FN, Sadi G, Yilmaz I (2020) A simple and sensitive fluorescent sensor platform for Al3+sensing in aqueous media and monitoring through combined PET and ESIPT mechanisms: Practical applications in drinking water and bio-imaging. New J Chem 44:12079–12089.
  27. Karuk Elmas SN, Dincer ZE, Erturk AS, Bostanci A, Karagoz A, Koca M, Sadi G, Yilmaz I (2020) A novel fluorescent probe based on isocoumarin for Hg2+ and Fe3+ ions and its application in live-cell imaging. Spectrochim Acta – Part A Mol Biomol Spectrosc 224:117402.
  28. Bal NB, Han S, Usanmaz SE, Kiremitci S, Sadi G, Uludag O, Demirel-Yilmaz E (2019) Activation of Liver X Receptors by GW3965 Attenuated Deoxycorticosterone Acetate-Salt Hypertension-Induced Cardiac Functional and Structural Changes. J Cardiovasc Pharmacol 74:105–117.
  29. Bal NB, Han S, Kiremitci S, Sadi G, Uludag O, Demirel-Yilmaz E (2019) Hypertension-induced cardiac impairment is reversed by the inhibition of endoplasmic reticulum stress. J Pharm Pharmacol 71:1809–1821.
  30. Sadi G, Sahin G, Bostanci A (2019) Modulation of Renal Insulin Signaling Pathway and Antioxidant Enzymes with Streptozotocin-Induced Diabetes: Effects of Resveratrol. Medicina 55:3.
  31. Derici MK, Sadi G, Cenik B, Güray T, Demirel-Yilmaz E (2019) Differential expressions and functions of phosphodiesterase enzymes in different regions of the rat heart. Eur J Pharmacol 844:118–129.
  32. Pektaş G, Pektaş SD, Öztekin A, Öztekin C, Neşelioğlu S, Erel Ö, Sadi G (2019) Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo. Arch Biol Sci 71:55–62.
  33. Yildirim OG, Sumlu E, Aslan E, Koca HB, Pektas MB, Sadi G, Akar F (2019) High-fructose in drinking water initiates activation of inflammatory cytokines and testicular degeneration in rat. Toxicol Mech Methods 29:224–232.
  34. Korkmaz OA, Sumlu E, Koca HB, Pektas MB, Kocabas A, Sadi G, Akar F (2019) Effects of lactobacillus plantarum and lactobacillus helveticus on renal insulin signaling, inflammatory markers, and glucose transporters in high-fructose-fed rats. Medicina 55:207.
  35. Korkmaz ÖA, Sadi G, Kocabaş A, Yildirim OG, Sumlu E, Koca HB, Nalbantoglu B, Pektaş MB, Akar F (2019) Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome. Arch Biol Sci 71:265–273.
  36. Han S, Bal NB, Sadi G, Usanmaz SE, Tuglu MM, Uludag MO, Demirel-Yilmaz E (2019) Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction. Vascul Pharmacol 113:38–46.
  37. Han S, Bal NB, Sadi G, Usanmaz SE, Uludag MO, Demirel-Yilmaz E (2018) The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta. Life Sci 213:287–293.
  38. Pektas MB, Turan O, Ozturk Bingol G, Sumlu E, Sadi G, Akar F (2018) High glucose causes vascular dysfunction through akt/eNOS pathway: Reciprocal modulation by juglone and resveratrol. Can J Physiol Pharmacol 96:757–764.
  39. Karuk Elmas ŞN, Ozen F, Koran K, Gorgulu AO, Sadi G, Yilmaz I, Erdemir S (2018) Selective and sensitive fluorescent and colorimetric chemosensor for detection of CO32- anions in aqueous solution and living cells. Talanta 188:614–622.
  40. Han S, Bal NB, Sadi G, Usanmaz SE, Uludag MO, Demirel-Yilmaz E (2018) The effects of resveratrol and exercise on age and gender-dependent alterations of vascular functions and biomarkers. Exp Gerontol 110:191–201.
  41. Altay A, Kartal DI, Sadi G, Güray T, Yaprak AE (2017) Modulation of mRNA expression and activities of xenobiotic metabolizing enzymes, CYP1A1, CYP1A2, CYP2E1, GPx and GSTP1 by the Salicornia freitagii extract in HT-29 human colon cancer cells. Arch Biol Sci 69:439–448.
  42. Emsen B, Kaya AKA, Cinar S, Aasim M, Sadi G (2017) In vitro cytotoxicity, antibacterial and antioxidant properties of various extracts from Schizophyllum commune Fr. Fresenius Environ Bull 26:1144–1153
  43. Pektas MB, Yücel G, Koca HB, Sadi G, Yıldırım OG, Öztürk G, Akar F (2017) Dietary Fructose-Induced Hepatic Injury in Male and Female Rats: Influence of Resveratrol. Drug Res (Stuttg) 67:103–110.
  44. Pektaş A, Pektaş MB, Koca HB, Tosun M, Aslan E, Koca S, Sadi G (2017) Effects of resveratrol on diabetes-induced vascular tissue damage and inflammation in male rats. Turkish J Biochem 42:451–458.
  45. Pektaş MB, Sadi G, Koca HB, Yuksel Y, Vurmaz A, Koca T, Tosun M (2016) Resveratrol Ameliorates the Components of Hepatic Inflammation and Apoptosis in a Rat Model of Streptozotocin-Induced Diabetes. Drug Dev Res 77:12–19.
  46. Sadi G, Kaya A, Yalcin HA, Emsen B, Kocabaş A, Kartal DI, Altay A (2016) Wild edible mushrooms from Turkey as possible anticancer agents on HepG2 cells together with their antioxidant and antimicrobial properties. Int J Med Mushrooms 18:83–95.
  47. Pektas MB, Koca HB, Sadi G, Akar F (2016) Dietary Fructose Activates Insulin Signaling and Inflammation in Adipose Tissue: Modulatory Role of Resveratrol. Biomed Res Int 2016:8014252.
  48. Sadi G, Konat D (2016) Resveratrol regulates oxidative biomarkers and antioxidant enzymes in the brain of streptozotocin-induced diabetic rats. Pharm Biol 54:1156–1163.
  49. Koca HB, Pektas MB, Koca S, Pektas G, Sadi G (2016) Diabetes-induced renal failure is associated with tissue inflammation and neutrophil gelatinase-associated lipocalin: Effects of resveratrol. Arch Biol Sci 68:747–752.
  50. Sadi G, Pektaş MB, Koca HB, Tosun M, Koca T (2015) Resveratrol improves hepatic insulin signaling and reduces the inflammatory response in streptozotocin-induced diabetes. Gene 570:213–220.
  51. Sadi G, Baloğlu MC, Pektaş MB (2015) Differential gene expression in liver tissues of streptozotocin-induced diabetic rats in response to resveratrol treatment. PLoS One 10:e0124968.
  52. Sadi G, Emsen B, Kaya A, Kocaba A, Çinar S, Kartal DI (2015) Cytotoxicity of some edible mushrooms extracts over liver hepatocellular carcinoma cells in conjunction with their antioxidant and antibacterial properties. Pharmacogn Mag 11:S6–S18.
  53. Pektaş MB, Sadi G, Akar F (2015) Long-Term Dietary Fructose Causes Gender-Different Metabolic and Vascular Dysfunction in Rats: Modulatory Effects of Resveratrol. Cell Physiol Biochem 37:1407–1420.
  54. Sadi G, Ergin V, Yilmaz G, Pektas MB, Yildirim OG, Menevse A, Akar F (2015) High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol. Eur J Nutr 54:895–904.
  55. Sadi G, Bozan D, Yildiz HB (2014) Redox regulation of antioxidant enzymes: Post-translational modulation of catalase and glutathione peroxidase activity by resveratrol in diabetic rat liver. Mol Cell Biochem 393:111–122.
  56. Sadi G, Kartal DI, Guray T (2013) Regulation of Glutathione S-Transferase Mu with type 1 diabetes and its regulation with antioxidants. Turkish J Biochem 38:92–10.
  57. Babacanoglu C, Yildirim N, Sadi G, Pektas MB, Akar F (2013) Resveratrol prevents high-fructose corn syrup-induced vascular insulin resistance and dysfunction in rats. Food Chem Toxicol 60:160–167.
  58. Sadi G, Eryilmaz N, Tütüncüoğlu E, Cingir Ş, Güray T (2012) Changes in expression profiles of antioxidant enzymes in diabetic rat kidneys. Diabetes Metab Res Rev 28:228–235.
  59. Sadi G, Güray T (2009) Gene expressions of Mn-SOD and GPx-1 in streptozotocin-induced diabetes: effect of antioxidants. Mol Cell Biochem 327:127–34.
  60. Sadi G, Yılmaz Ö, Güray T (2008) Effect of vitamin C and lipoic acid on streptozotocin-induced diabetes gene expression: mRNA and protein expressions of Cu-Zn SOD and catalase. Mol Cell Biochem 309:109–116.

B. Diğer Uluslararası Dergilerde Yayınlanan Makaleler

  1. Kütük A, Akar F, Sadi G (2023) Changes in hepatic thiol contents and regulation of glutathione S-transferase by high-fructose diet: Effects of kefir and some probiotic bacteria. Heal Sci Q 3:127–137 (TR-Dizin).
  2. Bostancı A, Sencan EN, Kütük A, Sadi G (2022) Differential regulation of antioxidant enzymes by resveratrol in healthy and cancerous hepatocytes. Anatol J Bot 6:62–68 (TR-Dizin).
  3. Sadi G, Bostancı A (2022) Reciprocal regulation of glycogen synthase kinase-3 and β-catenin affects cell proliferation of fructose treated rat hepatocytes. Heal Sci Q 2:91–99 (TR-Dizin).
  4. Şahin N, Emsen B, Aslan A, Sadi G (2021) Antioxidant potential of Pseudevernia furfuracea (L.) Zopf and its secondary metabolites on hepatocellular carcinoma cells: regulation of antioxidant enzymes. Anatol J Bot 5:127–133 (TR-Dizin).
  5. Kütük A, Sadi G (2020) Inhibitory effects of Armillaria mellea (Vahl) P. Kumm. on liver glutathione S-transferase activity. Anatol J Bot 4:1–7 (TR-Dizin).
  6. Köse MŞH, Dogan M, Sadi G (2020) Multiple shoot induction and plant regeneration of Staurogyne repens (Nees) Kuntze. Eurasian J Biol Chem Sci 3:106–109.
  7. Kose MSH, Dogan M, Sadi G (2020) Surface sterilization of Staurogyne repens (Nees) Kuntze with hydrogen peroxide. Bull Biotechnol 1:6–9
  8. Kol S, Bostanci A, Kocabaş A, Uzun Y, Sadi G (2018) Cell growth inhibitory potential of Craterellus cornucopioides ( L .) Pers . together with antioxidant and antimicrobial properties. Anatol J Bot 2:60–64 (TR-Dizin).
  9. Sadi G, Karabakan B, Aasim M (2017) Biochemical characterization of four different genotypes of Flax (Linum usitatissimum L .) seeds. Anatol J Bot 1:12–17 (TR-Dizin).
  10. Bakhsh A, Aasim M, Zia MAB, Doğan M, Sadi G, Karataş M, Khawar KM (2016) First Report of Agrobacterium tumefaciens mediated genetic transformation of aquatic Rice paddy herb (Limnophila aromatica). Turkish J Agric – Food Sci Technol 4:642 (TR-Dizin).
  11. Sadi G, Sadi Ö (2011) Diyabetik Sıçan Karaciğer Dokularında Oksidatif Hasar Parametrelerinin ve Antioksidan Enzimlerin Değişimleri. Res J Biol Sci 4:14–19
  12. Sadi G, Sadi Ö (2010) Reciprocal modulation of hepatic cytochrome P450 gene expressions with streptozotocin-induced diabetes and resveratrol. J Appl Biol Sci 4:55–62
  13. Sadi G, Sadi Ö (2010) Antioxidants and regulation of antioxidant enzymes by cellular redox status. Turkish J Sci Rev 3:95–107